Network mechanisms of ongoing brain activity’s influence on conscious visual perception

Description: Authors: Yuan-hao Wu, Ella Podvalny, Max Levinson, Biyu J. He. We employed whole-brain 7 Tesla fMRI data acquired during a threshold-level visual object recognition task in 25 healthy human subjects. Our objective was to dissect the influences of prestimulus brain activity from distributed cortical and subcortical brain regions on multiple facets of perceptual behavior, including the sensitivity and criterion of conscious object recognition, and discrimination accuracy in a categorization task. To shed light on the mechanisms linking prestimulus ongoing activity and perceptual behavior, we further investigated how prestimulus activity modulates stimulus-related processing. Our findings reveal a diverse set of effects on perceptual behavior exerted by prestimulus ongoing activity originating from distributed brain regions. High prestimulus activity in the ventromedial prefrontal cortex enhances sensitivity and promotes a more conservative criterion in object recognition by reducing the trial-to-trial variability of distributed stimulus-triggered responses. Prestimulus activity in the cingulo-opercular and visual networks had opposite influences on recognition-related criterion and discrimination accuracy, with prestimulus visual network activity modulating the variability and stimulus encoding in sensory-evoked responses, and prestimulus cingulo-opercular network activity exerting a pattern of influences consistent with the modulation of tonic alertness.

Related article: http://doi.org/10.1038/s41467-024-50102-9